منابع مشابه
Mesenchymal stem cells and cardiac repair
Accumulating clinical and experimental evidence indicates that mesenchymal stem cells (MSCs) are promising cell types in the treatment of cardiac dysfunction. They may trigger production of reparative growth factors, replace damaged cells and create an environment that favours endogenous cardiac repair. However, identifying mechanisms which regulate the role of MSCs in cardiac repair is still a...
متن کاملCardiac repair with allogeneic mesenchymal stem cells after myocardial infarction.
Over the past decade, use of autologous bone marrow-derived mononuclear cells (BMCs) has proven to be safe in phase-I/II studies in patients with myocardial infarction (MI). Taken as a whole, results support a modest yet significant improvement in cardiac function in cell-treated patients. Skeletal myoblasts, adipose-derived stem cells, and bone marrow-derived mesenchymal stem cells (MSCs) have...
متن کاملStem Cells and Cardiac Repair
Discovery of tissue specific stem cells capable of forming cardiac cell types has revolutionized cardiac medicine. Not long ago, cardiac tissue regeneration was considered an impossible task. The last ten years however has seen an explosion of cell based therapeutic approaches stimulating cardiac regeneration and in the process augmenting function in the heart following injury. Encouraging prec...
متن کاملPretreatment of Cardiac Stem Cells With Exosomes Derived From Mesenchymal Stem Cells Enhances Myocardial Repair.
BACKGROUND Exosomes derived from mesenchymal stem cells (MSCs) were proved to boost cell proliferation and angiogenic potency. We explored whether cardiac stem cells (CSCs) preconditioned with MSC exosomes could survive and function better in a myocardial infarction model. METHODS AND RESULTS DiI-labeled exosomes were internalized with CSCs. They stimulated proliferation, migration, and angio...
متن کاملMesenchymal Stem Cells: History, Isolation and Biology
Mesenchymal stem cells (MSCs) as a kind of adult stem cells possess two properties of long term selfrenewal ability and multilineage differentiation potential into skeletal cell lineages. MSCs were first isolated and described from bone marrow samples. Further investigations have identified several other tissues as alternative sources for these cells. In spite of the clinical importance of MSCs...
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ژورنال
عنوان ژورنال: Journal of Cellular and Molecular Medicine
سال: 2008
ISSN: 1582-1838
DOI: 10.1111/j.1582-4934.2008.00457.x